Beta emitters rhenium‐188 and lutetium‐177 are equally effective in radioimmunotherapy of HPV ‐positive experimental cervical cancer

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Beta emitters rhenium-188 and lutetium-177 are equally effective in radioimmunotherapy of HPV-positive experimental cervical cancer.

Cervical cancer caused by the infection with the human papillomavirus (HPV) remains the fourth leading killer of women worldwide. Therefore, more efficacious treatments are needed. We are developing radioimmunotherapy (RIT) of HPV-positive cervical cancers by targeting E6 and E7 viral oncoproteins expressed by the cancer cells with the radiolabeled monoclonal antibodies (mAbs). To investigate t...

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Detention of HPV L1 Capsid Protein and hTERC Gene in Screening of Cervical Cancer

  Objective(s): To investigate the expression of human papilloma virus (HPV) L1 capsid protein, and human telomerase RNA component (hTERC) in cervical cancer and the role of detection of both genes in screening of cervical cancer.   Materials and Methods: A total of 309 patients were recruited and cervical exfoliated cells were collected. Immunocytochemistry was employed to detect HPV L1 capsid...

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Molecular Identification of Human Papiloma Virus (HPV) in Cervical Neoplasia and the Risk Factors Affecting Cervical Cancer in Isfahan

The rate of cervical cancer in Asians is deferent, based on the risk factors affecting and the rate of papiloma virus infection among females. Cervical cancer is one of the important cancers between Iranian women. In the present study the rate of cervical neoplasia was detected in Isfahan and some risk factors affecting the incidence of cervical cancer was analyzed. The human papiloma virus inf...

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Study of Effective Factors in Cervical Cancer in Isfahan

ABSTRACT Cancer of the cervix is a common malignancy in females' genital tract. This is the third most common malignancy in females. The main object of this study was to determine the risk factors associated with cervical cancer. In this case-control study, from 282 cases, 87 patients with progressive disease were in the case group and 195 healthy women in the control group. Sampling method in...

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ژورنال

عنوان ژورنال: Cancer Medicine

سال: 2015

ISSN: 2045-7634,2045-7634

DOI: 10.1002/cam4.562